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Search Results for " cold-inducible rna-binding protein "

2

抑制剂 & 化合物

3

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T83729 Tat-CIRP TFA

Tat-Cold-inducible RNA Binding Protein

Tat-CIRP是一种肽类抑制剂,用于抑制髓样分化2蛋白(MD-2,亦称淋巴细胞抗原96 [LY96])与寒冷诱导的RNA结合蛋白(CIRP)之间的蛋白-蛋白相互作用。它通过与MD-2结合,干扰MD-2与CIRP之间的相互作用,这一作用在共免疫沉淀实验中得到证实。在体内实验中,Tat-CIRP (10及20 mg/kg) 能够减少由中脑动脉闭塞(MCAO)引发的小鼠脑梗死体积。同样,在通过血栓引发脑梗死的恒河猴模型中,Tat-CIRP同样能减少脑梗死体积,并缩短患中风一侧手臂抓取并放下食物的时间。
T80154 TAT-CIRP

TAT-CIRP为小肽,指Tat融合的冷诱导RNA结合蛋白。作为骨髓分化蛋白2(MD2)的抑制剂,该化合物对小鼠缺血性及出血性中风显示出显著的神经保护效果。

化合物

Tat-CIRP TFA
Cat.No: T83729
Synonym: Tat-Cold-inducible RNA Binding Protein
Target:
TAT-CIRP
Cat.No: T80154
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-03983 CIRBP Protein, Human, Recombinant (His)

cold inducible RNA binding

Human E. coli
CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator.CIRBP can bind the 3 translated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for...
TMPH-01110 CIRBP Protein, Human, Recombinant (GST)

A18HNRNP,CIRP,Glycine-rich RNA-binding

Human E. coli
CIRBP Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-02587 CIRBP Protein, Mouse, Recombinant (His)

CIRP,A18 hnRNP,Glycine-rich RNA-binding

Mouse E. coli
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.

重组蛋白

CIRBP Protein, Human, Recombinant (His)
Cat.No: TMPY-03983
Species: Human
Expression System: E. coli
CIRBP Protein, Human, Recombinant (GST)
Cat.No: TMPH-01110
Species: Human
Expression System: E. coli
CIRBP Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02587
Species: Mouse
Expression System: E. coli
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